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In a very modern review, we documented the identification as well as characterization of a fresh atypical opioid receptor with unique negative regulatory properties to opioid peptides.1 Our benefits showed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is usually a wide-spectrum scavenger for opio